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The reader will recall from Chapter 15 that T-bet is expressed exclusively in Th1 cells and induces transcription of the IFNγ gene. Forced expression of T-bet can also convert Th2 cells producing IL-4 and IL-5 into fully functional Th1 ...The near-invariant association of Eomes and T-bet with the CD122 hi state could be explained by several mechanisms: a common factor regulates Eomes, T-bet and CD122 in parallel; a CD122-mediated ...bet the ˈfarm/ˈranch (American English) risk everything that you have on something: It might succeed but don’t bet the farm on it. ♢ It’s a bet-the-farm situation.T-bet is found in Th1 but not in Th2 cells and is the key regulator of Th1 development and function. 16, 23 Mice lacking T-bet fail to develop Th1 cells and are driven toward Th2-mediated disease. 24 Overexpression of T-bet in Th2 cells results in loss of the Th2 phenotype and increased production of IFN-γ. 16 Activated T cells result in ...Jan 1, 2015 · Surface area is the means through which a solid interacts with its surroundings, especially liquids and gases. 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